Journal Article

Phytochemical and Toxicological Studies of Vitex doniana (Black Plum) Crude Extracts Against Albino Rats

Muhammad, I. L., Mohammed, A., Mohammed, J. N., 1Sani, A. R. Majin, S. N., 1Muhammad, R. G., Suleiman, A. L. and Ahmed, A.

Abstract

The study was carried out to determine the phytochemical and toxicological studies of Vitex doniana extracts against Albino rats. The phytochemical screening of Vitex doniana leaf and stem-bark extracts was evaluated using standard qualitative methods. Acute toxicity (LD50) was determined using oral administration methods. The phytochemical screening of all the crude extracts were found to have anthraquinones, flavonoids, glycosides, saponins, steroids, tannins and resins, while resins were absent in crude stem-bark extracts. The acute toxicity (LD50) of the Vitex doniana leaf and stem-bark extracts against albino rats was greater than 5000 mg/kg body weight and could be safe for use in human or higher animals. The result has justified their utilization by traditional medicine practitioners for the treatment of diarrhoea and other related ailments due to the presence of bioactive ingredients.

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